You have just discovered through testing that you have the MTHFR gene variant.  Now what?  These days there is so much information online regarding MTHFR that you initiate a self treatment protocol.    I understand this method as the internet recommendations seem so appropriate and clear.  Occasionally the answer might be this simple.  However, more often than not there are deeper issues or other genetic variants that need to be addressed.  Is your body absorbing the B12?   Did the supplementation with methyl folate and methyl cobalamin  exhibit adverse symptoms?

On a weekly basis we consult with numerous patients that have “MTHFR” variant and have tried the self treatment approach without benefit.  They are extremely frustrated at the lack of improvement or by the lack of knowledge by their primary care physician.


I will tell you it is much more complicated than prescribing methyl folate for the MTHFR gene variant.  I have had patients that are sensitive to increasing methylation such as methyl folate or methyl cobalamin.  The whole picture including other genetic snps (single nuclear polymorphisms) must be addressed along with the symptoms of the patient.  The MTHFR gene is an extremely important gene, and the most researched, but in of and by itself in only assists with a part of the clinical picture.  I adhere to the more comprehensive and personalized approach rather than taking a dart and hoping I hit a bullseye.


I have discovered it is much more beneficial to begin my protocols very slowly in low dosages to avoid any adverse reactions.  There are certain genes that need to be addressed before or after the MTHFR to successfully support the patient’s path to good health.  We must emphasize we do not treat the genes but rather the patient and their symptoms.


We are all provided with our unique set of genes and mutations.  As well we are all exposed to various environmental toxins, stress, bacteria and or viruses.  These epigenetic factors can lead to gene expression.  Just because we have a mutation does not necessarily mean we have expression.  The mutations lead us to susceptibility which can be supported through proper nutrition to minimize chances of expression.  When we analyze a genetic variant report we focus on all the genes as well as the patients symptoms and other lab results they might have.


  • Understand the big picture, analyze all the genes not just MTHFR
  • Epigenetics plays an important role
  • The Doctor you choose must understand Nutrigenomics
  • Your genes and your treatment are unique to you, there is no cookbook approach
  • Treatment is personalized
  • Seek a health professional that is familiar with MTHFR, Epigenetics, Nutrigenomics and COMPLETE Genetic Variant Report
  • Do not begin with methyl folates
  • Correlate Symptoms to Genetic Variants
  • Proper order of Supplementation for optimum results
  • Continued support to navigate the genetic roadmap

If you have any questions about our MTHFR protocols please contact us here.

Dr. Michael Veselak, D.C. BCIM CFMP

(805) 482-0723





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