Antibiotics such as Cipro, Levaquin, Avelox are a group of antibiotics called Floroquinolones. They are among the most commonly prescribed antibiotics in the United States.

With this class of antibiotics there are great risks that can come from taking these so make sure that when prescribed these that your condition is a serious one and not a minor problem like a UTI or sinus problem.

When I consult with people all over this country, several of the chronically ill have been “floxed” as has been termed, damaged by the Floroquinolones.   These individuals have had a neurotoxic reaction due to the ability of fluoride to penetrate the blood brain barrier and attack the brain.

I initially learned about this toxicity while researching for my book on Peripheral Neuropathy, “ Feet Don’t Fail Me Now.” Peripheral Neuropathy is just one of many problems that can occur due to this toxicity. More common symptoms are tingling, numbness, vertigo, loss of balance, memory issues, tendon ruptures, joint pain, ringing in the ears, rapid heart beat, intolerance to heat or cold, rashes.

So individuals that have been compromised by genetic susceptibilities, MTHFR, methylation, detoxification and the ability to handle chemicals and or toxins properly get a dose of these fluoride quinolones and this creates an inflammatory state in the body affecting the nervous system, musculoskeletal, gastrointestinal, and autonomic and cardiovascular system.

As we have learned with Genetics they can be turned on and off by diet and lifestyle changes. With floroquinones there can be an immediate reaction and or a cumulative effect where it actually will build up in the system and can affect you years down the road.

Is it possible that taking Cipro created the Peripheral Neuropathy or Tinnitus years down the road? Is this what idiopathic neuropathy is? Where there is no known identifiable cause but it is a chemical toxicity caused by an insult to our peripheral nervous system.

It has also been reported that this can than cause an increase in oxidative stress and consequential mitochondrial damage. This creates an incredible amount of fatigue, as the mitochondria function is to produce ATP, the energy of the cell. In my research with treating thousands of patients I have come to learn how important the mitochondria is for restoring a person back to health. In the past I would focus on adrenals and thyroid, which still play an important role, however if the mitochondria are not healthy than the body cannot protect itself from the continual onslaught of oxidative stress and the ability to produce energy, there will be no recovery.

Genetics does play a part. Besides the MTHFR gene, the CYP, NDUF, G6PD, NOS, CAT and SOD are important snps for methylation, detoxification and mitochondrial health.

There is no known cure for Floroquinolone toxicity however supporting the mitochondria, reducing oxidative stress, reducing brain inflammation, glutathione support and improve the detoxification pathways is a great place to start.

Functional Medicine focuses on finding the root cause of the problem. When discovered solutions become much clearer.





Anxiety is quickly becoming the most common complaint in my clinical practice as well as my online consultations.

The MTHFR gene plays a critical role in anxiety as well as depression.  When this gene expresses is creates an inability for our body to utilize folate in our body which is critical to many pathways in our body.

The two most researched genes with regards to anxiety and MTHFR are the A1298C and the C677T.

If you have the A1298C variant this can affect the biopterin pathway which can lead to problems such as:

  • Neurotransmitter disturbances (Which can lead to mood and behavior disorders such as depression, anxiety, ADD, ADHD and learning difficulties.)
  • Nutritional imbalances (Amino acid difficulties leading to neurotransmitter problems).

How much will you be affected if you have the A1298C gene mutation?

There are two different types of the A1298C gene mutations, these are referred to as heterozygous and homozygous.

  • Heterozygous = 1 copy of the gene from your father or mother
  • MTHFR A1298C heterozygous = 20-30% loss of function.
  • Homozygous = 2 copies of the gene, one each from your father or mother
  • MTHFR A1298C homozygous = 40% loss of function

Common Difficulties with the A1298C mutation

The majority of problems experienced with the A1298C gene mutation are associated with neurotransmitters.  Neurotransmitters such as dopamine, serotonin, norepinephrine and epinephrine.  These are chemicals that affect are mood, how we react to stress, our ability to focus and concentrate and our ability to relax.

For example, if you have the A1298C gene mutation you will have more of a propensity to have neurotransmitter issues.  This can lead to mood and behavior issues that can impact significantly ones health.

There are a few other genes that are important to look at when dealing with anxiety and depression. These genes are COMT, MAOa, MAOb, and GAD.  We must always look at the entire picture and not just focus on one gene.

The MTHFR gene is critical in the biopterin pathway and neurotransmitter production.  It is also critical in the Folate and Methionine Pathway and ultimately how it influences homocysteine, the production of glutathione and detoxification.

For those of you that have the MTHFR C677T gene mutation you will have symptoms associated with:

  • Folate metabolism
  • Homocysteine
  • Methylation issues
  • Nutritional imbalances Detoxification (reduced ability to detoxify properly leading to toxicity problems)

Similar to the A1298C mutation you can be heterozygous or homozygous, 1 or 2 copies of the gene from mom and or dad respectively.

  • MTHFR C677T heterozygous = 30-40% loss of MTHFR function
  • MTHFR C677T homozygous = 60-70% loss of MTHFR function

Generally the problems we see with the C677T mutation are elevated homocysteine, cardiovascular disease, stroke, heart attack or deep vein thrombosis.

The problems experienced by the C677T gene mutation include elevated homocysteine which can lead to cardiovascular disease, stroke, heart attack, deep vein thrombosis.  Family history of associated diseases is also common.

As you can see the MTHFR gene mutation can lead to some serious health issues.  I can’t stress enough the importance of consulting with a practitioner that understands the complexity of this issue as well as how epigenetics can affect you and nutrigenomics can reduce the risks associated with the mutation.

Can I have a combination of C677T and A1298C at the same time?

There are some people that have both the C677T and the A1298C gene mutation.  In these situations there can be a combination of symptoms including neurotransmitters, homocysteine elevation and folate metabolism.  Often times these situations become more complicated in trying to navigate the solution by yourself.  I highly recommend that you have the genetic profile be evaluated by a practitioner trained in this.  This will greatly improve the outcomes.

Please call us at 
(805) 482-0723 to schedule your consultation