Antibiotics such as Cipro, Levaquin, Avelox are a group of antibiotics called Floroquinolones. They are among the most commonly prescribed antibiotics in the United States.

With this class of antibiotics there are great risks that can come from taking these so make sure that when prescribed these that your condition is a serious one and not a minor problem like a UTI or sinus problem.

When I consult with people all over this country, several of the chronically ill have been “floxed” as has been termed, damaged by the Floroquinolones.   These individuals have had a neurotoxic reaction due to the ability of fluoride to penetrate the blood brain barrier and attack the brain.

I initially learned about this toxicity while researching for my book on Peripheral Neuropathy, “ Feet Don’t Fail Me Now.” Peripheral Neuropathy is just one of many problems that can occur due to this toxicity. More common symptoms are tingling, numbness, vertigo, loss of balance, memory issues, tendon ruptures, joint pain, ringing in the ears, rapid heart beat, intolerance to heat or cold, rashes.

So individuals that have been compromised by genetic susceptibilities, MTHFR, methylation, detoxification and the ability to handle chemicals and or toxins properly get a dose of these fluoride quinolones and this creates an inflammatory state in the body affecting the nervous system, musculoskeletal, gastrointestinal, and autonomic and cardiovascular system.

As we have learned with Genetics they can be turned on and off by diet and lifestyle changes. With floroquinones there can be an immediate reaction and or a cumulative effect where it actually will build up in the system and can affect you years down the road.

Is it possible that taking Cipro created the Peripheral Neuropathy or Tinnitus years down the road? Is this what idiopathic neuropathy is? Where there is no known identifiable cause but it is a chemical toxicity caused by an insult to our peripheral nervous system.

It has also been reported that this can than cause an increase in oxidative stress and consequential mitochondrial damage. This creates an incredible amount of fatigue, as the mitochondria function is to produce ATP, the energy of the cell. In my research with treating thousands of patients I have come to learn how important the mitochondria is for restoring a person back to health. In the past I would focus on adrenals and thyroid, which still play an important role, however if the mitochondria are not healthy than the body cannot protect itself from the continual onslaught of oxidative stress and the ability to produce energy, there will be no recovery.

Genetics does play a part. Besides the MTHFR gene, the CYP, NDUF, G6PD, NOS, CAT and SOD are important snps for methylation, detoxification and mitochondrial health.

There is no known cure for Floroquinolone toxicity however supporting the mitochondria, reducing oxidative stress, reducing brain inflammation, glutathione support and improve the detoxification pathways is a great place to start.

Functional Medicine focuses on finding the root cause of the problem. When discovered solutions become much clearer.





Anxiety is quickly becoming the most common complaint in my clinical practice as well as my online consultations.

The MTHFR gene plays a critical role in anxiety as well as depression.  When this gene expresses is creates an inability for our body to utilize folate in our body which is critical to many pathways in our body.

The two most researched genes with regards to anxiety and MTHFR are the A1298C and the C677T.

If you have the A1298C variant this can affect the biopterin pathway which can lead to problems such as:

  • Neurotransmitter disturbances (Which can lead to mood and behavior disorders such as depression, anxiety, ADD, ADHD and learning difficulties.)
  • Nutritional imbalances (Amino acid difficulties leading to neurotransmitter problems).

How much will you be affected if you have the A1298C gene mutation?

There are two different types of the A1298C gene mutations, these are referred to as heterozygous and homozygous.

  • Heterozygous = 1 copy of the gene from your father or mother
  • MTHFR A1298C heterozygous = 20-30% loss of function.
  • Homozygous = 2 copies of the gene, one each from your father or mother
  • MTHFR A1298C homozygous = 40% loss of function

Common Difficulties with the A1298C mutation

The majority of problems experienced with the A1298C gene mutation are associated with neurotransmitters.  Neurotransmitters such as dopamine, serotonin, norepinephrine and epinephrine.  These are chemicals that affect are mood, how we react to stress, our ability to focus and concentrate and our ability to relax.

For example, if you have the A1298C gene mutation you will have more of a propensity to have neurotransmitter issues.  This can lead to mood and behavior issues that can impact significantly ones health.

There are a few other genes that are important to look at when dealing with anxiety and depression. These genes are COMT, MAOa, MAOb, and GAD.  We must always look at the entire picture and not just focus on one gene.

The MTHFR gene is critical in the biopterin pathway and neurotransmitter production.  It is also critical in the Folate and Methionine Pathway and ultimately how it influences homocysteine, the production of glutathione and detoxification.

For those of you that have the MTHFR C677T gene mutation you will have symptoms associated with:

  • Folate metabolism
  • Homocysteine
  • Methylation issues
  • Nutritional imbalances Detoxification (reduced ability to detoxify properly leading to toxicity problems)

Similar to the A1298C mutation you can be heterozygous or homozygous, 1 or 2 copies of the gene from mom and or dad respectively.

  • MTHFR C677T heterozygous = 30-40% loss of MTHFR function
  • MTHFR C677T homozygous = 60-70% loss of MTHFR function

Generally the problems we see with the C677T mutation are elevated homocysteine, cardiovascular disease, stroke, heart attack or deep vein thrombosis.

The problems experienced by the C677T gene mutation include elevated homocysteine which can lead to cardiovascular disease, stroke, heart attack, deep vein thrombosis.  Family history of associated diseases is also common.

As you can see the MTHFR gene mutation can lead to some serious health issues.  I can’t stress enough the importance of consulting with a practitioner that understands the complexity of this issue as well as how epigenetics can affect you and nutrigenomics can reduce the risks associated with the mutation.

Can I have a combination of C677T and A1298C at the same time?

There are some people that have both the C677T and the A1298C gene mutation.  In these situations there can be a combination of symptoms including neurotransmitters, homocysteine elevation and folate metabolism.  Often times these situations become more complicated in trying to navigate the solution by yourself.  I highly recommend that you have the genetic profile be evaluated by a practitioner trained in this.  This will greatly improve the outcomes.

Please call us at 
(805) 482-0723 to schedule your consultation




On a weekly basis we consult with and receive numerous emails and phone calls from individuals with chronic health problems.  Recently, more of these people have already done their genetic testing through 23andme and have received their genetic variant report from companies like Livewello.   The difficulty however is how to navigate this complex roadmap of information.  Often times as we have all discovered it is not as easy as supporting just the MTHFR gene.


It is very important to remember it is not about supporting all the genetic variants that the reports suggest.  The key is to treat the patient, the actual symptoms not the genetic snps.   In our opinion to provide supplement advice as some of the genetic variant reports do is irresponsible and more often than not will not provide improvement of the symptoms.


As I have stated it is important to understand that every person is different in their symptoms and their genetics.  A cookbook approach of one size fits all for the most part just does not work effectively.  The benefits of  the genetic variant report is too correlate it with the patient symptoms as well as other labs to determine if the genes have actually expressed themselves.  The information than allows us to personalize treatment programs to each individual.


The MTHFR is the gene that there has been the most amount of research.  However, there is much more than supporting just the MTHFR gene. For instance there are some other genes that must be addressed when dealing with patients symptoms, such as COMT, CBS, CYP genes.  The entire picture must be analyzed and correlated with the individuals symptoms for optimum results.


We provide a personalized support program that considers your genetic raw data along with your symptoms to assist you in understanding your chronic health problems.   Dr. Veselak is Board Certified in Integrative Medicine and a Functional Medicine Practitioner.  This expertise provides him insight into providing you with the necessary tools to help you support and improve your current health symptoms.  He understands how the genetic variants can affect your symptoms and if the genes have actually expressed creating or enhancing the current health problems.



  • Discover the genes that are affecting your current health status
  • Provide you the tools to improve your health
  • Dietary and lifestyle changes to minimize or eliminate gene expression
  • Correlation of current symptoms with genetic variant report
  • Analysis of previous labs with genetic variant report
  • Recommendations of further testing if necessary
  • Access to a knowledgeable practitioner via phone, Skype or email for questions you have



  • You have your genetic variant report and want information as to what genes might be causing your symptoms and interfering with your ability to heal
  • Would like personalized care and follow up care
  • We offer 3, 6 and 12 month care programs
  • Our comprehensive programs provide recommendations for nutrition, lifestyle, dietary guidelines, review of labs, further testing
  • Email, phone or Skype consults available

Our office is accustomed to providing online distance consults.  So if you are having questions regarding your genetic variant reports please contact us here.

Dr. Michael Veselak, D.C. BCIM, CFMP

(805) 482-0723



MTHFR and Folic Acid

Why Folic Acid Is Bad For MTHFR

Diet and Lifestyle factors are very important for genetic expression.  Folic Acid if you have a MTHFR genetic variant is not good for you.  Folic Acid is not the same as Folate.  Folic Acid is actually the synthetic form of Folate; these are manmade substitutes for real Folate. Our bodies can’t process is and in many cases we lack the enzymes to convert it to a useable for. It takes our body 4 more steps to convert folic acid to L-methylfolate.  It requires the MTHFR gene.


The excess folic acid will be stored in the body as toxins in our tissues and organs.

Unfortunately, many foods these days are enriched with folic acid.  It has been added to foods such as bread and cereals because there was research that showed that it lowered the incidence of neural tube defects in newborn babies.

There is also research suggesting that with the supplementation of folic acid it can also increase the incidence of miscarriages due to the increased level of toxicity in the body.

Even in a lot of prenatal vitamins the folic acid, the synthetic form is found.  I have had patients that were having difficulty conceiving or had frequent miscarriages and once I ran the genetic test showing a MTHFR defect our treatment plan became more personalized.  In these cases we instructed the patient to avoid all supplements with folic acid and all fortified foods with folic acid.  It is important to read the labels on your food to avoid this common mistake.

There are other health problems associated with unmetabolized folic acid such as cognitive impairment, anemia and cytotoxicity.  The risk of supplementing with folic acid is too great.


  • Have genetic test to evaluate MTHFR gene
  • Read Food Labels
  • Avoid Folic Acid Supplementation


  • Eat green leafy vegetables
  • Supplement with Folinic Acid or Methyl Folate



You have just discovered through testing that you have the MTHFR gene variant.  Now what?  These days there is so much information online regarding MTHFR that you initiate a self treatment protocol.    I understand this method as the internet recommendations seem so appropriate and clear.  Occasionally the answer might be this simple.  However, more often than not there are deeper issues or other genetic variants that need to be addressed.  Is your body absorbing the B12?   Did the supplementation with methyl folate and methyl cobalamin  exhibit adverse symptoms?

On a weekly basis we consult with numerous patients that have “MTHFR” variant and have tried the self treatment approach without benefit.  They are extremely frustrated at the lack of improvement or by the lack of knowledge by their primary care physician.


I will tell you it is much more complicated than prescribing methyl folate for the MTHFR gene variant.  I have had patients that are sensitive to increasing methylation such as methyl folate or methyl cobalamin.  The whole picture including other genetic snps (single nuclear polymorphisms) must be addressed along with the symptoms of the patient.  The MTHFR gene is an extremely important gene, and the most researched, but in of and by itself in only assists with a part of the clinical picture.  I adhere to the more comprehensive and personalized approach rather than taking a dart and hoping I hit a bullseye.


I have discovered it is much more beneficial to begin my protocols very slowly in low dosages to avoid any adverse reactions.  There are certain genes that need to be addressed before or after the MTHFR to successfully support the patient’s path to good health.  We must emphasize we do not treat the genes but rather the patient and their symptoms.


We are all provided with our unique set of genes and mutations.  As well we are all exposed to various environmental toxins, stress, bacteria and or viruses.  These epigenetic factors can lead to gene expression.  Just because we have a mutation does not necessarily mean we have expression.  The mutations lead us to susceptibility which can be supported through proper nutrition to minimize chances of expression.  When we analyze a genetic variant report we focus on all the genes as well as the patients symptoms and other lab results they might have.


  • Understand the big picture, analyze all the genes not just MTHFR
  • Epigenetics plays an important role
  • The Doctor you choose must understand Nutrigenomics
  • Your genes and your treatment are unique to you, there is no cookbook approach
  • Treatment is personalized
  • Seek a health professional that is familiar with MTHFR, Epigenetics, Nutrigenomics and COMPLETE Genetic Variant Report
  • Do not begin with methyl folates
  • Correlate Symptoms to Genetic Variants
  • Proper order of Supplementation for optimum results
  • Continued support to navigate the genetic roadmap

If you have any questions about our MTHFR protocols please contact us here.

Dr. Michael Veselak, D.C. BCIM CFMP

(805) 482-0723